Hufnagel T J, Savino P J, Zimmerman R A, Sergott R C
Department of Ophthalmology, Yale University School of Medicine, New Haven, Connecticut.
Can J Ophthalmol. 1990 Feb;25(1):38-41.
Progressive cranial nerve palsies and painful ophthalmoplegia developed in a 76-year-old man with lentigo maligna of the forehead 18 months after the excision of a spindle cell tumour of the forehead that proved on immunohistochemical study to be a malignant melanoma. The signs and symptoms were caused by neurotropic spread of the malignant melanoma into the cavernous sinus and subsequent neurosarcomatous transformation of the orbital metastasis.
一名76岁男性，前额患有恶性雀斑样痣，在切除前额梭形细胞瘤18个月后出现进行性颅神经麻痹和疼痛性眼肌麻痹。免疫组织化学研究证实该梭形细胞瘤为恶性黑色素瘤。这些体征和症状是由于恶性黑色素瘤向海绵窦的神经嗜性扩散以及眼眶转移灶随后发生神经肉瘤样转化所致。
