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促纤维增生性黑色素瘤累及眼眶。

Orbital involvement with desmoplastic melanoma.

作者信息

Shields J A, Elder D, Arbizo V, Hedges T, Augsburger J J

出版信息

Br J Ophthalmol. 1987 Apr;71(4):279-84. doi: 10.1136/bjo.71.4.279.

DOI:10.1136/bjo.71.4.279
PMID:3580340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1041143/
Abstract

A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prior skin lesion by neurotropic mechanisms. The occurrence of a desmoplastic neurotropic melanoma in the orbit has not been previously recognised. The problems in the clinical and pathological diagnosis of this rare type of melanoma are discussed.

摘要

一名79岁女性在鼻部皮肤黑色素瘤切除五年半后出现眼眶肿物。最初的眼眶活检组织病理学诊断为恶性纤维组织细胞瘤，但特殊染色和电子显微镜检查显示其为促纤维增生性恶性黑色素瘤，显然是通过嗜神经机制从先前的皮肤病变扩散至眼眶。眼眶促纤维增生性嗜神经黑色素瘤的发生此前尚未被认识到。本文讨论了这种罕见类型黑色素瘤在临床和病理诊断方面的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/8fbebe74420a/brjopthal00614-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/2f9c20a6945a/brjopthal00614-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/670a48dcc3cb/brjopthal00614-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/45e909e2983f/brjopthal00614-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/6a35e65c88c1/brjopthal00614-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/9009d9ba0e3b/brjopthal00614-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/ca09f5cff84a/brjopthal00614-0038-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/4d477b3425d1/brjopthal00614-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/01cb9600cb07/brjopthal00614-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/41eb096c2fd1/brjopthal00614-0039-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/8fbebe74420a/brjopthal00614-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/2f9c20a6945a/brjopthal00614-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/670a48dcc3cb/brjopthal00614-0037-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/45e909e2983f/brjopthal00614-0037-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/6a35e65c88c1/brjopthal00614-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/9009d9ba0e3b/brjopthal00614-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/ca09f5cff84a/brjopthal00614-0038-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/4d477b3425d1/brjopthal00614-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/01cb9600cb07/brjopthal00614-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/41eb096c2fd1/brjopthal00614-0039-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d751/1041143/8fbebe74420a/brjopthal00614-0040-a.jpg

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Metastatic Melanoma to the Orbit With Dedifferentiation: A Case Report.眼眶转移性黑色素瘤伴去分化：病例报告
Cureus. 2023 Jul 9;15(7):e41591. doi: 10.7759/cureus.41591. eCollection 2023 Jul.
3
Desmoplastic melanoma: a diagnostic dilemma.促纤维增生性黑色素瘤：诊断难题。

本文引用的文献

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Desmoplastic malignant melanoma: a case report.
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Desmoplastic malignant melanoma of the upper eyelid.上睑促纤维增生性恶性黑色素瘤
J Clin Diagn Res. 2013 Jun;7(6):1172-3. doi: 10.7860/JCDR/2013/4722.3026. Epub 2013 Jun 1.
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Primary malignant melanoma of the orbit arising in a cellular blue naevus.起源于细胞性蓝色痣的眼眶原发性恶性黑色素瘤。
Br J Ophthalmol. 1989 May;73(5):388-93. doi: 10.1136/bjo.73.5.388.
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Desmoplastic malignant melanoma (a rare variant of spindle cell melanoma).促纤维增生性恶性黑色素瘤（梭形细胞黑色素瘤的一种罕见变体）。
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Neurotropic melanoma of the face invading the maxillary nerve.
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