抗精神病药所致精神分裂症和心境障碍患者神经系统副作用的比较研究。
A comparative study of neuroleptic induced neurological side effects in schizophrenia and mood disorders.
机构信息
P.N. SURESH KUMAR, M.B.B.S., D.P.M., Resident, Central Institute of Psychiatry, Kanke, Ranchi.
出版信息
Indian J Psychiatry. 1997 Apr;39(2):110-4.
Neuroleptic induced neurological side effects were compared over a period of one year (1991-1992) in 45 schizophrenics and age and sex matched 42 mood disorder patients, diagnosed as per DSM-III-R criteria. Prevalence of dystonia was equally common in both groups. Pseudoparkinsonism was significantly high in female mood disorder patients, akathisia in middle aged mood disorder patients and tradive dyskinesia in mood disorder patients. Factors like age of onset, time of onset and mean dose of antipsychotics (chlorpromazine equivalent) did not show any significant difference. The findings are discussed in relation to their practical application and suggestions for future studies are outlined.
在为期一年的时间里（1991-1992 年），我们对 45 名精神分裂症患者和年龄、性别匹配的 42 名心境障碍患者的神经阻滞剂引起的神经系统副作用进行了比较，这些患者的诊断均符合 DSM-III-R 标准。两组患者的肌张力障碍发生率相当。女性心境障碍患者中帕金森综合征样症状明显较多，中年心境障碍患者静坐不能较多，心境障碍患者有迟发性运动障碍。发病年龄、发病时间和抗精神病药物（氯丙嗪当量）的平均剂量等因素无显著差异。本文对这些发现进行了讨论，并就其实际应用提出了一些建议。
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