Mukherjee S, Rosen A M, Caracci G, Shukla S
Arch Gen Psychiatry. 1986 Apr;43(4):342-6. doi: 10.1001/archpsyc.1986.01800040052008.
The prevalence and outcome of persistent tardive dyskinesia (TD) was studied in 131 bipolar patients. There were 34 cases of persistent TD in the subgroup (n = 96) with a history of neuroleptic treatment (prevalence, 35.4%; 95% confidence interval, 25% to 45%); there were no cases of persistent TD in the subgroup (n = 35) without such treatment history. Except in one patient, signs of TD persisted in spite of lithium carbonate treatment in 23 patients (median duration, 16 months; range, five to 24 months), of whom 15 remained off of a neuroleptic regimen during the study period for a median duration of 14 months (range, four to 24 months). Using multiple regression analysis, two variables were found to predict the presence of persistent TD and account for 36% of the variance: longer cumulative duration of maintenance neuroleptic treatment and shorter duration of previous lithium carbonate treatment. There appears to be a significant risk of persistent TD among neuroleptic-treated bipolar patients. High-risk subgroups within this category need to be identified.
对131例双相情感障碍患者的持续性迟发性运动障碍（TD）的患病率及转归进行了研究。在有抗精神病药物治疗史的亚组（n = 96）中有34例持续性TD（患病率为35.4%；95%置信区间为25%至45%）；在无此类治疗史的亚组（n = 35）中无持续性TD病例。除1例患者外，23例患者尽管接受了碳酸锂治疗，TD症状仍持续存在（中位持续时间为16个月；范围为5至24个月），其中15例在研究期间停用了抗精神病药物治疗方案，中位持续时间为14个月（范围为4至24个月）。通过多元回归分析，发现有两个变量可预测持续性TD的存在，并解释36%的方差：维持性抗精神病药物治疗的累计持续时间较长和既往碳酸锂治疗的持续时间较短。在接受抗精神病药物治疗的双相情感障碍患者中，似乎存在持续性TD的显著风险。需要确定该类别中的高危亚组。
