Wegner J T, Catalano F, Gibralter J, Kane J M
Arch Gen Psychiatry. 1985 Sep;42(9):860-5. doi: 10.1001/archpsyc.1985.01790320028004.
We investigated the role neurologic soft signs, premorbid asociality, psychometric tests, and family history of psychiatric illness may play in the identification of patients at risk for tardive dyskinesia (TD) development. Thirty-two TD and 32 non-TD schizophrenics served as subjects. The results indicated that patients with TD have more soft signs, are more frequently rated as poor premorbid asocials, perform more poorly on psychometric testing, and have a familial loading for affective disorders in first-degree relatives higher than control patients. A discriminant function analysis correctly classified 84.4% of the patients into their respective groups. Subtle yet quantifiable differences exist between TD and non-TD patients and these deficits may render the individual more vulnerable to TD development.
我们研究了神经软体征、病前社会性差、心理测试以及精神疾病家族史在识别迟发性运动障碍（TD）发病风险患者中可能发挥的作用。32名TD患者和32名非TD精神分裂症患者作为研究对象。结果表明，TD患者有更多软体征，病前社会性差的评级更频繁，心理测试表现更差，且一级亲属中情感障碍的家族负荷高于对照患者。判别函数分析将84.4%的患者正确分类到各自的组中。TD患者和非TD患者之间存在细微但可量化的差异，这些缺陷可能使个体更容易发生TD。
