强迫症：氯米帕明、催乳素与治疗反应。
Obsessive compulsive neurosis : clomipramine, prolactin and therapeutic response.
机构信息
JAMBUR ANANTH, M.D., Harbor-UCLA Medical Center, 1000 W, Carson Street, Building 1-South Torrance, CA 90509, USA.
出版信息
Indian J Psychiatry. 1997 Apr;39(2):154-9.
This study was designed to assess the relationship between psychopathology and serotonin generated prolactin response to clomipramine and to assess the relationship between improvement in psychopathology and prolactin levels. The experimental sample consisted of 15 patients in the drug and 12 patients in the placebo groups. Blood samples for prolactin levels were drawn at baseline, and at the end of 4,8, and 12 weeks. There were statistically significant differences in prolactin increase between the drug and the placebo groups at 4 but not at 12 weeks following treatment. When the four least improved and a similar number of the most improved patients were compared, the least improved patients had the most increase in prolactin and the most improved had the least increase.
本研究旨在评估精神病理学与氯米帕明诱导的血清素生成催乳素反应之间的关系，并评估精神病理学改善与催乳素水平之间的关系。实验组包括 15 名药物组患者和 12 名安慰剂组患者。在基线时以及治疗后第 4、8 和 12 周时抽取催乳素水平的血样。在治疗后第 4 周，药物组与安慰剂组之间的催乳素增加存在统计学显著差异，但在第 12 周时没有差异。当比较四例改善最少和同样数量改善最多的患者时，改善最少的患者催乳素增加最多，改善最多的患者催乳素增加最少。
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