Hanna G L, McCracken J T, Cantwell D P
Division of Mental Retardation and Child Psychiatry, University of California, Los Angeles.
J Am Acad Child Adolesc Psychiatry. 1991 Mar;30(2):173-8. doi: 10.1097/00004583-199103000-00002.
Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.
在治疗前，对18名患有强迫症的儿童和青少年测量了基础催乳素浓度，并在其中15名患者接受氯米帕明治疗4周和8周后再次进行测量。基础催乳素水平受慢性抽动障碍病史以及强迫症状的持续时间和严重程度影响。服用氯米帕明显着提高了基础催乳素水平。在氯米帕明治疗的最后4周内，催乳素水平略有下降，这与良好的治疗反应呈正相关，与病程呈负相关。如果在氯米帕明治疗期间观察到的催乳素水平变化主要是由于血清素能神经传递的变化，那么这些数据表明，氯米帕明治疗强迫症会使血清素能受体的反应性产生适应性降低。
