Barton W. Palmer, University of California, San Diego; V.A Medical Center, 3350 La Jolla Village Drive Lo Jolla, CA 92961, USA.
Indian J Psychiatry. 1996 Jan;38(1):13-22.
A review of literature on the neurodevelopmental origins of schizophemia is presented, with particular attention to neurodevelopmental processes in late-onset schizophemia. Definitions of the term "neurodevelopmental" as used in schizophernia literature are first provided. Next, evidence for the developmental origins of the neuropathology in schizophemia is reviewed. This evidence includes studies of the associations between schizophemia and neurodevelopmental brain aberrations, minor physical anomalies, obstetric complications, prenatal viral exposure, childhood neuromotor abnormalities, and pandysmaturation. A brief discussion of the predominant theories about the neurodevelopmental origins of schizophemia is then provided. The concept and nature of "late-onset schizophenia "is next defined and discussed. Finally, the neurodevelopmental literature is discussed in relation to the phenomenon of late-onset schizophemia. Based on this review, we conclude that there exists a strong likelihood that late-onset schizophrenia involves neurodevelopmental processes.
本文回顾了精神分裂症神经发育起源的文献，特别关注了晚发性精神分裂症的神经发育过程。首先提供了在精神分裂症文献中使用的术语“神经发育”的定义。接下来，回顾了精神分裂症神经病理学的发育起源的证据。这些证据包括精神分裂症与神经发育性脑异常、轻微身体异常、产科并发症、产前病毒暴露、儿童神经运动异常和 pandysmaturation 之间的关联研究。然后简要讨论了关于精神分裂症神经发育起源的主要理论。接下来定义并讨论了“晚发性精神分裂症”的概念和性质。最后，根据这篇综述，我们得出结论，晚发性精神分裂症很可能涉及神经发育过程。
