Buckley P F
Northcoast Behavioral Healthcare System and Case Western Reserve University, Cleveland, Ohio, USA.
J Nerv Ment Dis. 1998 Feb;186(2):79-86. doi: 10.1097/00005053-199802000-00003.
The neurodevelopmental hypothesis of schizophrenia is currently a primary etiopathological model for schizophrenia. Its tenets derive from observations of epidemiological, postmortem, and brain imaging evidence of neurodevelopmental deviance. Clinical stigmata of neurodevelopmental arrest include the presence of obstetric complications, minor physical anomalies, abnormal dermatoglyphics, and childhood neuromotor precursors of adult schizophrenic illness. The relative importance of these stigmata and their relationship to brain imaging findings in schizophrenia are discussed.
精神分裂症的神经发育假说目前是精神分裂症的主要病因病理模型。其原理源于对神经发育异常的流行病学、尸检及脑成像证据的观察。神经发育停滞的临床特征包括产科并发症、轻微身体异常、异常皮纹以及成年精神分裂症的童年神经运动先兆。本文讨论了这些特征在精神分裂症中的相对重要性及其与脑成像结果的关系。
