Kohno N, Miyake M, Inoue Y, Yokoyama A, Hiwada K, Tanabe M, Yamakido M, Kyoizumi S, Akiyama M
KITANO HOSP,TAZUKE KOFUKAI MED RES INST,DEPT THORAC SURG,KITAKU,OSAKA 530,JAPAN. RADIAT EFFECTS RES FDN,DEPT RADIAT BIOL,MINAMI KU,HIROSHIMA 732,JAPAN. HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 2,MINAMI KU,HIROSHIMA 734,JAPAN.
Int J Oncol. 1992 Nov;1(6):649-55. doi: 10.3892/ijo.1.6.649.
We discovered a circulating mucin-like antigen designated as CAM-14 detected by a new murine monoclonal antibody KL-14 (IgM). We found different heat resistant properties between serum CAM- 14 from normal individuals and from lung cancer patients. Heat treatment had less effect on the levels of CAM-14 in sera from lung cancer patients, whereas CAM-14 levels in sera from normal individuals were markedly decreased after heat treatment at tempratures > 65-degrees-C. As a serum tumor marker, CAM- 14 had only very low levels of false-positive values with a high specificity and effectively increased the positive rate for lung cancer patients when used together with carcinoembryonic antigen.
我们发现了一种循环的粘蛋白样抗原，命名为CAM-14，它可被一种新的鼠单克隆抗体KL-14（IgM）检测到。我们发现正常个体和肺癌患者血清中的CAM-14具有不同的耐热特性。热处理对肺癌患者血清中CAM-14水平的影响较小，而正常个体血清中的CAM-14水平在温度>65摄氏度热处理后明显降低。作为一种血清肿瘤标志物，CAM-14的假阳性值水平极低，特异性高，与癌胚抗原一起使用时可有效提高肺癌患者的阳性率。
