Kohno N, Hirasawa Y, Kondo K, Fujioka S, Fujino S, Abe M, Yokoyama A, Hiwada K, Watanabe K, Nishimura J
Second Department of Internal Medicine, Ehime University School of Medicine, Japan.
Cancer Detect Prev. 1997;21(2):124-8.
Carcinoembryonic antigen (CEA) has been clinically used as a serum marker for lung cancer, especially for pulmonary adenocarcinoma. Since we had developed a tumor marker against pulmonary adenocarcinoma, CAM 123-6 belonging to KL-6 MUC 1 mucin, we compared its clinical value with that of CEA, in combination with squamous cell carcinoma-related antigen (SCC) and neuron-specific enolase (NSE). The subjects were 30 patients with adenocarcinoma, 23 with squamous cell carcinoma, 16 with small cell carcinoma, and 20 with benign lung disease. For discriminating lung cancer from benign lung disease, the combination of CAM 123-6, SCC, and NSE showed 64% diagnostic accuracy, and the combination of CEA, SCC, and NSE 65%. In differentiating pulmonary adenocarcinoma from other lung cancer, the diagnostic accuracy of CAM 123-6 was 81% and that of CEA was 74%, although there was no significant difference between them. These observations indicate that the diagnostic accuracy of CAM 123-6 is similar to that of CEA. Neither marker is sufficiently specific to differentiate pulmonary adenocarcinoma from other forms of lung cancer.
癌胚抗原（CEA）已在临床上用作肺癌尤其是肺腺癌的血清标志物。由于我们研发了一种针对肺腺癌的肿瘤标志物，即属于KL-6 MUC 1粘蛋白的CAM 123-6，我们将其与CEA的临床价值进行了比较，并结合了鳞状细胞癌相关抗原（SCC）和神经元特异性烯醇化酶（NSE）。研究对象包括30例腺癌患者、23例鳞状细胞癌患者、16例小细胞癌患者和20例良性肺病患者。为了区分肺癌与良性肺病，CAM 123-6、SCC和NSE联合检测的诊断准确率为64%，CEA、SCC和NSE联合检测的诊断准确率为65%。在区分肺腺癌与其他类型肺癌时，CAM 123-6的诊断准确率为81%，CEA为74%，尽管两者之间无显著差异。这些观察结果表明，CAM 123-6的诊断准确率与CEA相似。两种标志物都没有足够的特异性来区分肺腺癌与其他形式的肺癌。
