Bezrukova L V, Solntseva E I
Neirofiziologiia. 1981;13(6):589-93.
Morphine which was added to the extracellular solution in a concentration of 1.10(-5) M, rapidly and reversibly depressed depolarizing (15 cells of 20) and hyperpolarizing (6 cells of 12) serotonin (1.10(-6) M) responses of neurons of the mollusc Helix lucorum. The depressing morphine effect was antagonized by naloxone (1.10(-5) M). The results suggest involvement of an opiate receptor mechanism. Dose-response curves for serotonin before morphine application and in the presence of morphine show a noncompetitive mechanism of morphine-serotonin interaction.
向细胞外溶液中添加浓度为1.10(-5)M的吗啡后，能迅速且可逆地抑制福寿螺神经元的去极化（20个细胞中的15个）和超极化（12个细胞中的6个）5-羟色胺（1.10(-6)M）反应。纳洛酮（1.10(-5)M）可拮抗吗啡的抑制作用。结果提示存在阿片受体机制。应用吗啡前及应用吗啡时5-羟色胺的剂量反应曲线显示吗啡与5-羟色胺的相互作用为非竞争性机制。
