de Luis A, Montalbán J, Fernández J M, Ocaña I, Codina A, Martínez-Vázquez J M
Servicio de Medicina Interna-Patología Infecciosa, Hospital General Vall d'Hebron, Universitat Autónoma, Barcelona.
Med Clin (Barc). 1990 Jan 20;94(2):49-52.
We report five patients with human immunodeficiency virus (HIV) infection in stages IV-C1, IV-C2 and IV-D who developed peripheral polyneuropathy (PNP). Two patients had invalidating PNP with a demyelinating predominance, while in the remaining three axonal component predominated. However, both components were present in different degrees in all patients. We have observed two cases with transition from one type of PNP to the other during the course of the disease. Inflammatory polyradiculoneuropathy usually develops in the initial stages of the infection, while the distal axonal type is more commonly seen in patients with advanced infection. The possibility that PNP could have, in these patients, a common etiology and pathogenesis with variable clinical and electrophysiological expression is discussed.
我们报告了5例处于IV - C1、IV - C2和IV - D期的人类免疫缺陷病毒（HIV）感染患者，他们发生了周围性多发性神经病（PNP）。2例患者患有致残性PNP，以脱髓鞘为主，而其余3例以轴突成分占主导。然而，所有患者均不同程度地存在这两种成分。我们观察到2例患者在病程中从一种类型的PNP转变为另一种类型。炎性多发性神经根神经病通常在感染初期发生，而远端轴突型在晚期感染患者中更常见。本文讨论了在这些患者中PNP可能具有共同病因和发病机制，但临床和电生理表现各异的可能性。
