Abel E L, Subramanian M, Zajac C S
Fetal Alcohol Research Center, Wayne State University, Detroit, Michigan.
Life Sci. 1990;46(13):903-8. doi: 10.1016/0024-3205(90)90091-5.
The potential contribution of maternal age to tetrahydrocannabinol's (THC) in utero effects in rats was studied. Pregnant animals were intubated with 25, 10 or 0 mg/kg of THC from gestation day six to parturition. Animals in the 10 and 0 mg/kg groups were pair fed to those given the 25 mg/kg dose. Each series of doses was administered to females three, four or six months of age. THC lowered maternal weight gain and weights of offspring at birth and at 21 days of age, but did not affect litter size, spontaneous alternation or passive avoidance learning in offspring. Increased maternal age was associated with smaller litter size and lower birth weight and weight at 21 days, but did not interact significantly with THC.
研究了母体年龄对大鼠子宫内四氢大麻酚（THC）影响的潜在作用。从妊娠第6天至分娩，给怀孕动物分别灌胃25、10或0mg/kg的THC。10mg/kg和0mg/kg组的动物与给予25mg/kg剂量的动物进行配对喂食。将每组剂量分别给予3、4或6月龄的雌性动物。THC降低了母体体重增加以及子代出生时和21日龄时的体重，但不影响子代的窝仔数、自发交替行为或被动回避学习。母体年龄增加与窝仔数减少以及出生体重和21日龄时体重降低有关，但与THC无显著交互作用。
