Hutchings D E, Morgan B, Brake S C, Shi T, Lasalle E
Neurotoxicol Teratol. 1987 Jan-Feb;9(1):39-43. doi: 10.1016/0892-0362(87)90068-7.
Either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (THC) in sesame oil was administered by gastric intubation to gravid rats during the last two weeks of gestation. A pair-fed control group was administered the vehicle alone and allowed to eat and drink only the amount consumed by the 50 mg/kg group on the same gestation days. A nontreated control group was left undisturbed during pregnancy. All treated and control litters were fostered at birth to untreated dams. Among the dams receiving 50 mg/kg of THC, food and water intake was initially reduced to 75-80% of nontreated controls but then recovered over 3-4 days to approximately a 15-20% reduction until term. Compared with the nontreated dams, both THC dose-level groups and pair-fed control dams gained significantly less body weight from conception to term. Offspring mortality did not differ between the nontreated and pair-fed controls but was significantly higher among both dose-level THC exposed groups. In addition, there was a dose-related increase in the sex-ratio of live male to female offspring as well as significant effects on rate of growth for both sexes. The results are discussed with respect to published animal and clinical studies of cannabinoid exposure during pregnancy.
在妊娠的最后两周，通过胃管给妊娠大鼠灌胃给予芝麻油中15或50毫克/千克的δ-9-四氢大麻酚（THC）。一对配对喂养的对照组仅给予赋形剂，并允许其在相同妊娠日仅进食和饮水50毫克/千克组所消耗的量。一个未处理的对照组在怀孕期间不做任何处理。所有处理组和对照组的幼崽在出生时都寄养给未处理的母鼠。在接受50毫克/千克THC的母鼠中，食物和水的摄入量最初降至未处理对照组的75 - 80%，但随后在3 - 4天内恢复，直至足月时减少约15 - 20%。与未处理的母鼠相比，两个THC剂量水平组和配对喂养的对照母鼠从受孕到足月体重增加显著较少。未处理组和配对喂养对照组的后代死亡率没有差异，但在两个剂量水平的THC暴露组中显著更高。此外，存活雄性与雌性后代的性别比呈剂量相关增加，并且对两性的生长速率都有显著影响。根据已发表的关于孕期接触大麻素的动物和临床研究对结果进行了讨论。
