Abel E L, Tan S E
Department of Obstetrics, Wayne State University, Detroit, Michigan 48201.
Reprod Toxicol. 1987;1(1):37-40. doi: 10.1016/0890-6238(87)90069-4.
Delta-9-tetrahydrocannabinol (THC), chlordiazepoxide hydrochloride (Librium) or a combination of these drugs, were administered to pregnant mice on gestation days 6 to parturition. Levels of THC in blood were dose-related and approximated levels attained in humans after smoking one to two marijuana cigarettes. Blood cannabinoid levels in mice were elevated by concurrent administration of chlordiazepoxide. Maternal weight gain was significantly reduced by THC but not by chlordiazepoxide. Neither drug affected implantations, but THC significantly increased resorptions. Both THC and chlordiazepoxide decreased fetal weight. There was no indication of synergism between the two drugs for any of the measures examined in this study.
在妊娠第6天至分娩期间，给怀孕小鼠施用Δ-9-四氢大麻酚（THC）、盐酸氯氮卓（利眠宁）或这两种药物的组合。血液中THC的水平与剂量相关，接近人类吸食一到两支大麻香烟后达到的水平。同时施用氯氮卓可提高小鼠血液中大麻素水平。THC显著降低母体体重增加，但氯氮卓没有此作用。两种药物均不影响着床，但THC显著增加吸收。THC和氯氮卓均降低胎儿体重。在本研究中检测的任何指标上，两种药物之间均未显示协同作用。
