Department of Ophthalmology, St. Franziskus Hospital, Muenster, Germany.
Acta Ophthalmol. 2011 Sep;89(6):e521-7. doi: 10.1111/j.1755-3768.2011.02162.x. Epub 2011 May 17.
To evaluate the prognostic value of anterior chamber (AC) laser flare (LF) in uveitis associated with juvenile idiopathic arthritis (JIA).
Monocentre, retrospective study of 150 JIA children (girls n = 107, 71.3%) with unilateral or bilateral chronic anterior uveitis (statistical analysis of one eye per patient). LF values (KOWA FM-500), visual acuity, intraocular pressure, glaucoma treatment and uveitis complications were investigated longitudinally.
Patients were followed up for a mean of 8.7 months (range 1-36). High LF values correlated with poor visual acuity (p < 0.0001). Patients with low LF values (LF ≤ 20 photon units per millisecond) less often required glaucoma medication (p = 0.0005) or surgery (p = 0.01) and showed a lower prevalence of cataract, band keratopathy, posterior synechiae, epiretinal membrane, optic disc oedema and glaucoma/ocular hypertension (p < 0.05, each). Baseline LF > 20 photon units per millisecond was a better prognosticator for the development of subsequent complications than baseline AC cells (p = 0.04).
High LF values in patients with JIA uveitis are associated with poor vision and a higher prevalence of uveitis complications.
评估前房（AC）激光闪烁（LF）在与幼年特发性关节炎（JIA）相关的葡萄膜炎中的预后价值。
单中心、回顾性研究了 150 名 JIA 儿童（女孩 n = 107，71.3%），他们患有单侧或双侧慢性前葡萄膜炎（对每位患者的一只眼进行统计分析）。纵向研究 LF 值（KOWA FM-500）、视力、眼内压、青光眼治疗和葡萄膜炎并发症。
患者平均随访 8.7 个月（范围 1-36）。高 LF 值与视力差相关（p < 0.0001）。LF 值低（LF ≤ 20 光子/毫秒）的患者较少需要青光眼药物治疗（p = 0.0005）或手术（p = 0.01），并且白内障、带状角膜病变、后粘连、视网膜前膜、视盘水肿和青光眼/高眼压的发生率较低（p < 0.05，每项）。与基线 AC 细胞相比，基线 LF > 20 光子/毫秒是预测随后发生并发症的更好指标（p = 0.04）。
JIA 葡萄膜炎患者的高 LF 值与视力差和葡萄膜炎并发症的发生率较高相关。
