Intermountain Medical Center & University of Utah, Murray, USA.
Clin Exp Rheumatol. 2011 Jan-Feb;29(1 Suppl 64):S92-8. Epub 2011 May 11.
Vasculitis affecting large elastic arteries, including the aorta and major proximal branches, encompasses various diseases including Takayasu arteritis, giant cell (or temporal) arteritis, and tertiary syphilis, but also may occur as a rare complication of Behçet's disease, rheumatoid arthritis, sarcoidosis, Cogan syndrome, Kawasaki disease, ankylosing spondylitis, systemic lupus erythematosus and Wegener's granulomatosis. Recent reports have also established a link between inflammatory abdominal aortic aneurysm as well as lymphoplasmacytic thoracic aortitis with an overabundance of IgG4-producing plasma cells and the burgeoning constellation of 'Hyper-IgG4' syndromes. This review focuses on morphologic aspects of large-vessel vasculitis pathology associated with giant cell arteritis, Takayasu arteritis, idiopathic or isolated aortitis, lymphoplasmacytic thoracic and ascending aortitis, and the inflammatory aneurysm/retroperitoneal fibrosis syndrome.
累及大动脉弹性层的血管炎，包括主动脉及其主要近端分支，涵盖了多种疾病，包括 Takayasu 动脉炎、巨细胞（颞）动脉炎和三期梅毒，也可能作为 Behçet 病、类风湿关节炎、结节病、Cogan 综合征、川崎病、强直性脊柱炎、系统性红斑狼疮和 Wegener 肉芽肿等罕见并发症出现。最近的报告还确立了炎症性腹主动脉瘤以及富含 IgG4 产生浆细胞的淋巴浆细胞性胸主动脉炎与不断增加的“高 IgG4”综合征之间的联系。本文主要聚焦于与巨细胞动脉炎、Takayasu 动脉炎、特发性或孤立性主动脉炎、淋巴浆细胞性胸主动脉和升主动脉炎以及炎症性腹主动脉瘤/腹膜后纤维化综合征相关的大动脉血管炎病理学的形态学方面。
