Royal Hobart Hospital, Hobart, TAS, Australia.
J Med Case Rep. 2021 Sep 28;15(1):478. doi: 10.1186/s13256-021-03067-y.
Graft-versus-host disease is a common complication seen with allogenic stem cell transplant, which is used to treat a variety of hematological malignancies. Graft-versus-host disease is an allogenic syndrome and can present in a variety of ways, including symptoms mimicking various autoimmune diseases; however, it is quite rare to see graft-versus-host disease affecting the vascular system and causing vasculitis.
We describe a case of a 59-year-old Caucasian man with follicular lymphoma and diffuse large B-cell transformation who developed graft-versus-host disease post allogenic hematopoietic stem cell transplantation and later progressed to neurological complication foot drop and large-vessel vasculitis.
The life-threatening vascular complications associated with large-vessel vasculitis include arterial aneurysms and dissections, and ischemic or hemorrhagic stroke. Thus, this rare immunological association needs to be recognized and treated in a timely manner to prevent the long-term complications.
移植物抗宿主病是异体干细胞移植中常见的并发症，用于治疗各种血液系统恶性肿瘤。移植物抗宿主病是一种异体综合征，可以以多种方式表现出来，包括模仿各种自身免疫性疾病的症状；然而，非常罕见的是看到移植物抗宿主病影响血管系统并导致血管炎。
我们描述了一例 59 岁的白种人男性，患有滤泡性淋巴瘤和弥漫性大 B 细胞转化，在异体造血干细胞移植后发生移植物抗宿主病，后来进展为神经并发症足下垂和大血管血管炎。
与大血管血管炎相关的危及生命的血管并发症包括动脉动脉瘤和夹层，以及缺血性或出血性中风。因此，需要及时识别和治疗这种罕见的免疫相关疾病，以预防长期并发症。
