Research Institute MOVE, Department of Rehabilitation Medicine, Physical Therapy Section, VU University Medical Center, The Netherlands.
Mult Scler. 2011 Oct;17(10):1231-7. doi: 10.1177/1352458511407102. Epub 2011 May 17.
Both fatigue and reduced physical activity are important consequences of multiple sclerosis (MS). However, their mutual association is poorly understood.
The objective of the study was to determine the relation between perceived fatigue and home-based recording of motor activity in patients with MS.
Found associations were checked for confounding by age, Expanded Disability Status Scales (EDSS), disease duration, sub-type of MS, anxiety, and depression. Forty-three ambulatory patients with MS were recruited. Ambulatory physical activity was recorded for 24 hours. Fatigue was assessed with the Fatigue Severity Scale (FSS), the Modified Fatigue Impact Scale (MFIS) and the Checklist Individual Strength (CIS20R). Linear regression was applied after which potential confounding factors were introduced in a multivariate regression model.
No significant associations between physical activity and fatigue scores were found, except for the MFIS sub-scale 'physical activity' (ß(physical_activity) [ß(pa)] = -0.044; SE = 0.020). The association between physical activity and the FSS score was distorted by age, MS-type, anxiety and depression and the association between physical activity and the MFIS score by age and depression. The inverse association between MFIS sub-scale 'physical activity' and physical activity was significantly strengthened by adjusting for age (ß(pa) = - 0.052; SE = 0.019), sub-type of MS (ß(pa) = - 0.048; SE = 0.020), anxiety (ß(pa) = - 0.070; SE = 0.023) and depression (ß(pa) = - 0.083; SE = 0.023).
In MS, there is no, or at best a weak association between severity of perceived fatigue and physical activity. Depending on the fatigue questionnaire used, patient characteristics such as age, type of MS, depression and anxiety are factors that may affect this relationship.
疲劳和体力活动减少都是多发性硬化症（MS）的重要后果。然而，它们之间的相互关系还了解甚少。
本研究的目的是确定 MS 患者感知疲劳与家庭运动活动记录之间的关系。
检查了与年龄、扩展残疾状况量表（EDSS）、疾病持续时间、MS 亚型、焦虑和抑郁相关的关联。招募了 43 名活动性 MS 患者。记录了 24 小时的身体活动。疲劳用疲劳严重程度量表（FSS）、改良疲劳影响量表（MFIS）和个体力量检查表（CIS20R）进行评估。应用线性回归，然后在多变量回归模型中引入潜在的混杂因素。
除 MFIS 子量表“体力活动”（ß（physical_activity）[ß（pa）] = -0.044；SE = 0.020）外，体力活动与疲劳评分之间未发现显著关联。体力活动与 FSS 评分之间的关联被年龄、MS 类型、焦虑和抑郁所扭曲，而体力活动与 MFIS 评分之间的关联则被年龄和抑郁所扭曲。调整年龄后，MFIS 子量表“体力活动”与体力活动之间的反向关联显著增强（ß（pa）= -0.052；SE = 0.019），MS 亚型（ß（pa）= -0.048；SE = 0.020），焦虑（ß（pa）= -0.070；SE = 0.023）和抑郁（ß（pa）= -0.083；SE = 0.023）。
在 MS 中，感知疲劳的严重程度与体力活动之间没有或几乎没有关联。根据使用的疲劳问卷，患者的特征，如年龄、MS 类型、抑郁和焦虑，可能是影响这种关系的因素。
