Key Laboratory of Forest Genetics and Biotechnology of Ministry of Education, Nanjing Forestry University, Nanjing 210037, China.
Bioinformatics. 2011 Jul 15;27(14):2006-8. doi: 10.1093/bioinformatics/btr306. Epub 2011 May 17.
Functional mapping that embeds the developmental mechanisms of complex traits shows great power to study the dynamic pattern of genetic effects triggered by individual quantitative trait loci (QTLs). A full-sib family, produced by crossing two heterozygous parents, is characteristic of uncertainties about cross-type at a locus and linkage phase between different loci. Integrating functional mapping into a full-sib family requires a model selection procedure capable of addressing these uncertainties. 3FunMap, written in VC++ 6.0, provides a flexible and extensible platform to perform full-sib functional mapping of dynamic traits. Functions in the package encompass linkage phase determination, marker map construction and the pattern identification of QTL segregation, dynamic tests of QTL effects, permutation tests and numerical simulation. We demonstrate the features of 3FunMap through real data analysis and computer simulation.
功能映射将复杂性状的发育机制嵌入其中，对于研究由个体数量性状位点 (QTL) 触发的遗传效应的动态模式具有巨大的力量。由两个杂合亲本杂交产生的全同胞家系，其特点是在一个位点上的杂交类型和不同位点之间的连锁相位存在不确定性。将功能映射整合到全同胞家系中需要一个能够解决这些不确定性的模型选择过程。3FunMap 是用 VC++ 6.0 编写的，为动态性状的全同胞功能映射提供了一个灵活和可扩展的平台。该软件包中的功能包括连锁相位确定、标记图谱构建和 QTL 分离模式识别、QTL 效应的动态检验、置换检验和数值模拟。我们通过实际数据分析和计算机模拟展示了 3FunMap 的特点。
