Nat Chem Biol. 2011 Jun;7(6):344-5. doi: 10.1038/nchembio.587.
STIM proteins are ubiquitous endoplasmic reticulum Ca sensors that rapidly translocate to couple with ‘store-operated’ Orai Ca channels when luminal Ca levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.
STIM 蛋白是普遍存在的内质网 Ca 传感器，当腔室内 Ca 水平较低时，它们会迅速转移并与“储存操作”的 Orai Ca 通道偶联。STIM1 还能感知热变化，这会引发类似的转移，并使 STIM1 为激活 Orai 做好准备，这表明 STIM1 作为多种应激信号的传感器发挥作用。
