Mishra Sunil K, Kumar A, Talukdar A
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi - 221 005, India.
Pharmacognosy Res. 2010 Sep;2(5):289-92. doi: 10.4103/0974-8490.72325.
Litsea glitinosa is an evergreen tree of medium size which grows to a height of about 20 to 30 feet. It belongs to family Lauraceae. In India it is found mainly in North Eastern region. The leaves and the mucilage from the bark of plant is utilized in the gum for poultices.
Mucilage of Litsea glutinosa was isolated from powdered bark by continuous hot extraction technique using water and precipitation by absolute alcohol (38% w/w yield). The mucilage was evaluated for binding properties in tablets and granules, using paracetamol as a model drug. The granules were prepared using 4 different concentrations of mucilage (4%, 6%, 8%, and 10%) and evaluated for percentage of fines, average particle size, total porosity, compressibility index, and flow properties. The prepared tablets were evaluated for content uniformity, hardness, friability, disintegration time, and in vitro dissolution profiles.
The results obtained with the lower concentrations of mucilage, that is, less than 6% were not so encouraging. The tablets prepared by using 10% mucilage of L. glutinosa as binder exhibited more hardness as compared with the starch.
It may be concluded that the concentration ranging from 6% to 8% of L. glutinosa mucilage may be considered as better option as a binding agent for the preparation of tablets as compared to the starch (10%).
潺槁木姜子是一种中型常绿乔木，可长至约20至30英尺高。它属于樟科。在印度，它主要分布在东北地区。该植物树皮的叶子和黏液被用于制作膏药的胶。
采用连续热萃取技术，用水从粉碎的树皮中分离出潺槁木姜子黏液，并用无水乙醇沉淀（产率为38% w/w）。以对乙酰氨基酚为模型药物，评估该黏液在片剂和颗粒剂中的黏合性能。使用4种不同浓度的黏液（4%、6%、8%和10%）制备颗粒剂，并评估细粉百分比、平均粒径、总孔隙率、压缩指数和流动性能。对制备的片剂进行含量均匀度、硬度、脆碎度、崩解时间和体外溶出曲线评估。
较低浓度黏液（即低于6%）得到的结果不太理想。与淀粉相比，使用10%潺槁木姜子黏液作为黏合剂制备的片剂表现出更高的硬度。
可以得出结论，与淀粉（10%）相比，6%至8%浓度的潺槁木姜子黏液作为片剂制备的黏合剂可能是更好的选择。
