外源性环巴胺——一种稳定且强效的 Hedgehog 信号通路抑制剂。
Exo-cyclopamine--a stable and potent inhibitor of hedgehog-signaling.
机构信息
Institut für Organische Chemie, Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, D-04103 Leipzig, Germany.
出版信息
Chem Commun (Camb). 2011 Jul 14;47(26):7362-4. doi: 10.1039/c1cc11782c. Epub 2011 May 17.
PMID:21589966
Abstract
The combination of theoretical and computational studies with organic synthesis and biological investigations has led to exo-cyclopamine. This stable and highly potent derivative of cyclopamine promises big potential as an experimental drug against several types of human cancer.
摘要
理论和计算研究与有机合成和生物研究的结合产生了外-环巴胺。这种环巴胺的稳定且高活性衍生物有望成为对抗多种人类癌症的实验药物，具有巨大的潜力。
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