Department of Chemistry, The University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
Org Lett. 2011 Sep 16;13(18):4786-9. doi: 10.1021/ol2017966. Epub 2011 Aug 15.
Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic structure are reported.
先前在本实验室的工作表明, readily available(现成的)环巴胺 F 环芳构类似物是 Hedgehog 信号传导的高效抑制剂。报告了两种 F 环饱和类似物的合成和生物评价,它们比 F 环芳构体更有效。