基于环巴胺的 F 环饱和雌酮衍生 Hedgehog 信号抑制剂的立体选择性合成。
Stereoselective synthesis of F-ring saturated estrone-derived inhibitors of Hedgehog signaling based on cyclopamine.
机构信息
Department of Chemistry, The University of Pennsylvania , Philadelphia, Pennsylvania 19104, USA.
出版信息
Org Lett. 2011 Sep 16;13(18):4786-9. doi: 10.1021/ol2017966. Epub 2011 Aug 15.
Abstract
Previous work in this laboratory established that the readily available F-ring aromatic analog of cyclopamine is a highly potent inhibitor of Hedgehog signaling. The synthesis and biological evaluation of two F-ring saturated analogs that are more potent than the F-ring aromatic structure are reported.
摘要
先前在本实验室的工作表明， readily available（现成的）环巴胺 F 环芳构类似物是 Hedgehog 信号传导的高效抑制剂。报告了两种 F 环饱和类似物的合成和生物评价，它们比 F 环芳构体更有效。
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