C-H 功能化策略指导卡巴他赛类似物的合成。

C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog.

机构信息

Universität Leipzig, Institut für Organische Chemie, Johannisallee 29, D-04103 Leipzig, Germany.

Rice University, Department of Chemistry, BioScience Research Collaborative, 6100 Main St., Houston, Texas 77005, United States.

出版信息

Beilstein J Org Chem. 2014 Jul 9;10:1564-9. doi: 10.3762/bjoc.10.161. eCollection 2014.

DOI:10.3762/bjoc.10.161

PMID:25161712

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4142839/

Abstract

The chemical synthesis of carbacyclopamine analog 2, a cyclopamine analog with an all-carbon E-ring, is reported. The use of C-H-functionalization logic and further metal-catalyzed transformations allows for a concise entry to this new class of acid-stable cyclopamine analogs.

摘要

报道了全碳 E 环的环巴胺类似物 2 的化学合成。C-H 官能化逻辑的使用和进一步的金属催化转化允许简洁地进入这一类新型酸稳定的环巴胺类似物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f6a/4142839/9de0ae24c650/Beilstein_J_Org_Chem-10-1564-g002.jpg

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C-H 功能化策略指导卡巴他赛类似物的合成。

C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog.

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C-H 功能化策略指导卡巴他赛类似物的合成。

C-H-Functionalization logic guides the synthesis of a carbacyclopamine analog.

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出版信息

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