Nishi M, Yoshida K, Hirata K, Miyake H
SAPPORO MED UNIV,DEPT SURG 1,SAPPORO,HOKKAIDO 060,JAPAN.
Oncol Rep. 1997 Sep-Oct;4(5):995-8. doi: 10.3892/or.4.5.995.
In order to investigate the relation between the occurrence of colorectal cancer and food consumption in Hokkaido, Japan, etiological factors of colorectal cancer were investigated through an ecologic study using official food consumption and mortality statistics concerning colorectal cancer, and through a community-based case-control study. The ratio of 'animal foods' to 'plant foods' and that of 'animal protein' to 'plant protein' had a significant correlation with the mortality rate in colorectal cancer. The percentage of fat energy was much more contributory than the absolute amount of fat. Traditional Japanese foods tended to prevent while Western foods tended to promote colorectal cancer. Odds ratios for Japanese foods were low for colon cancer, and those for Western foods were high for rectum cancer. Relative amounts of foods are more contributory than their absolute amounts. An increase of colorectal cancer in Japanese people may be attributable to the increase in the relative amounts of Western foods. Reduction of the ratio of animal foods to plant foods (i.e., a reduction in relative amounts of Western foods or an increase in relative amounts of Japanese foods) may lend to the prevention of colorectal cancer.
为了研究日本北海道地区结直肠癌的发生与食物消费之间的关系，通过一项利用官方食物消费和结直肠癌死亡率统计数据的生态学研究，以及一项基于社区的病例对照研究，对结直肠癌的病因因素进行了调查。“动物性食物”与“植物性食物”的比例以及“动物蛋白”与“植物蛋白”的比例与结直肠癌死亡率显著相关。脂肪能量的百分比比脂肪的绝对量贡献更大。传统日本食物倾向于预防结直肠癌，而西方食物倾向于促进结直肠癌。日本食物对结肠癌的优势比低，而西方食物对直肠癌的优势比高。食物的相对量比其绝对量贡献更大。日本人结直肠癌发病率的增加可能归因于西方食物相对量的增加。降低动物性食物与植物性食物的比例（即减少西方食物的相对量或增加日本食物的相对量）可能有助于预防结直肠癌。
