Department of Pneumology and Allergy, Medical University of Lodz, Kopcińskiego 22, 90-153 Łódź, Poland.
Inflammation. 2012 Apr;35(2):554-9. doi: 10.1007/s10753-011-9345-1.
Nitric oxide (NO) production and carbon monoxide (CO) production are increased in inflammatory lung diseases. Although there are some pieces of evidence for hormonal modulation by estrogen, little is known about exhaled NO and CO during the ovarian cycle. In 23 subjects, we measured exhaled NO and CO by an online analyzer. Significantly higher levels of exhaled NO were found at the midcycle compared with those in the premenstrual period or during menstruation. Higher levels of CO were after ovulation and reached a peak in the premenstrual phase. The lowest levels of CO were observed in the first days of the estrogen phase. In males, there was no significant variation in exhaled NO and CO. Exhaled NO and CO levels vary during the ovarian cycle in women, and this fact should be taken into account during serial measurements of these markers in the female population.
一氧化氮（NO）和一氧化碳（CO）的产生在炎症性肺部疾病中增加。虽然有一些证据表明雌激素对激素有调节作用，但在卵巢周期期间，关于呼出的 NO 和 CO 知之甚少。在 23 名受试者中，我们通过在线分析仪测量了呼出的 NO 和 CO。与月经前期或月经期间相比，排卵中期呼出的 NO 水平明显更高。CO 水平在排卵后升高，并在月经前期达到峰值。CO 水平最低出现在雌激素期的最初几天。在男性中，呼出的 NO 和 CO 没有明显变化。在女性中，呼出的 NO 和 CO 水平在卵巢周期中发生变化，因此在女性人群中对这些标志物进行连续测量时应考虑到这一事实。
