Dragan Ecaterina S, Bucatariu Florin
"Petru Poni" Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41 A, 700487 Iasi, Romania.
Macromol Rapid Commun. 2010 Feb 2;31(3):317-22. doi: 10.1002/marc.200900630. Epub 2009 Nov 18.
Novel multilayer thin films that consist solely of cross-linked single component layers are generated by a selective cross-linking of the poly(vinyl amine) (PVAm) layers in PVAm/poly(acrylic acid) (PAA) thin films constructed either on silica particles or silicon wafers, followed by the removal of PAA. The surface topography of the (PVAm)(n) multilayer thin films, before and after the adsorption of human serum albumin (HSA), has been studied by atomic force microscopy on the freeze-dried films. The decrease of the average roughness of the film after the adsorption of HSA showed the protein was adsorbed into the (PVAm)(n) film making these films potential reservoirs for proteins.
仅由交联单组分层组成的新型多层薄膜是通过对在二氧化硅颗粒或硅片上构建的聚乙烯胺（PVAm）/聚丙烯酸（PAA）薄膜中的PVAm层进行选择性交联，然后去除PAA而生成的。通过原子力显微镜对冻干薄膜进行研究，考察了人血清白蛋白（HSA）吸附前后（PVAm）(n)多层薄膜的表面形貌。HSA吸附后薄膜平均粗糙度的降低表明蛋白质被吸附到（PVAm）(n)薄膜中，使这些薄膜成为蛋白质的潜在储存库。
