Strandberg-Larsen Katrine, Skov-Ettrup Lise Skrubbeltrang, Grønbaek Morten, Andersen Anne-Marie Nybo, Olsen Jørn, Tolstrup Janne
Social Medicine Section of, Department of Public Health, University of Copenhagen, Denmark.
Birth Defects Res A Clin Mol Teratol. 2011 Jul;91(7):616-22. doi: 10.1002/bdra.20818. Epub 2011 May 17.
This cohort study examines the possible association between maternal alcohol intake, including binge drinking, during pregnancy, and the subsequent risk of having a child with an isolated congenital heart defect and, more specifically, with the isolated form of ventricular septal defect (VSD) or of an atrial septal defect (ASD).
Participants were 80,346 pregnant women who were enrolled into the Danish National Birth Cohort in 1996-2002 and gave birth to a live-born singleton without any chromosome anomalies. Twice during pregnancy these women were asked about their intake of alcohol. Few (if any) women with an excessive/abusive intake of alcohol were enrolled into the Danish National Birth Cohort.
Through linkage with the National Hospital Discharge Registry, we identified 477 infants with a diagnosis of isolated congenital heart defect registered at any time during their first 3½-years of life; they included 198 infants with a VSD and 145 with an ASD. Neither the number of episodes of binge drinking nor binge drinking during three different developmental periods was associated with VSD or ASD. Women drinking ½-1½, 2, and 3+ drinks of alcohol per week had adjusted prevalence ratios of delivering an infant with a VSD of 1.22 (95% CI = 0.90-1.66); 1.38 (95% CI = 0.83-2.28); and 1.10 (95% CI = 0.54-2.23), respectively. The test for trend was 0.29.
Prenatal exposure to low-to-moderate levels of alcohol on a weekly basis or occasional binge drinking during the early part of pregnancy was not statistical significantly associated with the prevalence of isolated VSD and ASD in offspring.
这项队列研究探讨孕期母亲饮酒（包括暴饮）与子代患单纯性先天性心脏病，尤其是单纯性室间隔缺损（VSD）或房间隔缺损（ASD）风险之间的可能关联。
研究对象为1996 - 2002年纳入丹麦国家出生队列的80346名孕妇，她们均分娩了无任何染色体异常的单胎活产儿。孕期两次询问这些女性的饮酒情况。极少（如果有的话）酗酒/滥用酒精的女性被纳入丹麦国家出生队列。
通过与国家医院出院登记处的关联，我们确定了477名在出生后头3.5年中任何时间被诊断为单纯性先天性心脏病的婴儿；其中包括198名患有室间隔缺损的婴儿和145名患有房间隔缺损的婴儿。暴饮次数以及三个不同发育阶段的暴饮均与室间隔缺损或房间隔缺损无关。每周饮用半杯至1.5杯、2杯和3杯以上酒精饮料的女性，分娩患室间隔缺损婴儿的校正患病率分别为1.22（95%CI = 0.90 - 1.66）；1.38（95%CI = 0.83 - 2.28）；和1.10（95%CI = 0.54 - 2.23）。趋势检验P值为0.29。
孕期每周低至中度饮酒或孕早期偶尔暴饮与子代单纯性室间隔缺损和房间隔缺损的患病率无统计学显著关联。
