Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou, PR China.
Pharm Biol. 2011 Sep;49(9):989-93. doi: 10.3109/13880209.2010.551780. Epub 2011 May 18.
Fructus Corni is derived from the dry ripe sarcocarp of Cornus officinalis Sieb. et Zucc. (Cornaceae). Morroniside is an active constituent of Fructus Corni used in many traditional Chinese medicines (TCMs). This article describes a sensitive and specific assay for the quantitation of morroniside in rat plasma after oral administration of iridoid glycosides from Fructus Corni.
In this article, back-propagation (BP) neural network method was fist developed for the prediction of pharmacokinetic (PK) parameters of morroniside in Fructus Corni.
The results show that mean square error (MSE) of neural network model with 11 hidden neurons and 90% training data is 0.092.
This article provides a new method to calculate PK data, one do not need to figure out all the compartment parameters to acquire PK data of morroniside. Therefore, the BP neural network method would be useful for guiding the holistic PK study in consistence with the intrinsic theory and characteristics of TCM.
山茱萸来源于山茱萸科山茱萸的干燥成熟果肉。莫诺苷是山茱萸中用于许多中药（TCM）的一种活性成分。本文描述了一种灵敏、特异的方法，用于测定山茱萸中环烯醚萜苷给药后大鼠血浆中莫诺苷的含量。
本文首次采用反向传播（BP）神经网络法预测山茱萸中环烯醚萜苷的莫诺苷的药代动力学（PK）参数。
结果表明，在 11 个隐藏神经元和 90%训练数据的神经网络模型中，均方误差（MSE）为 0.092。
本文提供了一种计算 PK 数据的新方法，无需确定所有隔室参数即可获得莫诺苷的 PK 数据。因此，BP 神经网络方法将有助于指导与 TCM 的内在理论和特征一致的整体 PK 研究。
