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心脏病中的线粒体功能障碍:.的潜在治疗作用

Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of .

作者信息

Cao Xinxin, Yao Fan, Zhang Bin, Sun Xiaobo

机构信息

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing, China.

出版信息

Front Pharmacol. 2023 Jul 20;14:1218803. doi: 10.3389/fphar.2023.1218803. eCollection 2023.

DOI:10.3389/fphar.2023.1218803
PMID:37547332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10399631/
Abstract

Heart diseases have a high incidence and mortality rate, and seriously affect people's quality of life. Mitochondria provide energy for the heart to function properly. The process of various heart diseases is closely related to mitochondrial dysfunction. (), as a traditional Chinese medicine, is widely used to treat various cardiovascular diseases. Many studies have confirmed that and ginsenosides can regulate and improve mitochondrial dysfunction. Therefore, the role of mitochondria in various heart diseases and the protective effect of on heart diseases by regulating mitochondrial function were reviewed in this paper, aiming to gain new understanding of the mechanisms, and promote the clinical application of .

摘要

心脏病具有高发病率和死亡率,严重影响人们的生活质量。线粒体为心脏正常运作提供能量。各种心脏病的发病过程与线粒体功能障碍密切相关。()作为一种传统中药,被广泛用于治疗各种心血管疾病。许多研究证实,()和人参皂苷可以调节并改善线粒体功能障碍。因此,本文综述了线粒体在各种心脏病中的作用以及()通过调节线粒体功能对心脏病的保护作用,旨在对其机制有新的认识,并促进()的临床应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/67fdacc01f00/fphar-14-1218803-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/199a3dd85e86/fphar-14-1218803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/d8a1970bf7e1/fphar-14-1218803-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/bb7445bba49c/fphar-14-1218803-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/0bc491a9a02f/fphar-14-1218803-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/67fdacc01f00/fphar-14-1218803-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/199a3dd85e86/fphar-14-1218803-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/d8a1970bf7e1/fphar-14-1218803-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/bb7445bba49c/fphar-14-1218803-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/0bc491a9a02f/fphar-14-1218803-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a16/10399631/67fdacc01f00/fphar-14-1218803-g005.jpg

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本文引用的文献

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Discrepancy Study of the Chemical Constituents of Panax Ginseng from Different Growth Environments with UPLC-MS-Based Metabolomics Strategy.不同生长环境人参化学成分的差异性研究:基于 UPLC-MS 的代谢组学策略。
Molecules. 2023 Mar 24;28(7):2928. doi: 10.3390/molecules28072928.
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Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms.人参抗心肌缺血/再灌注损伤:临床前证据及潜在机制综述
J Ethnopharmacol. 2023 Jan 10;300:115715. doi: 10.1016/j.jep.2022.115715. Epub 2022 Sep 13.
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Signaling Pathways Related to Oxidative Stress in Diabetic Cardiomyopathy.
人参皂苷 Rb1-PLGA 纳米粒的制备、表征及体内药代动力学研究。
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糖尿病心肌病中与氧化应激相关的信号通路。
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Ginsenoside Rk1 inhibits cell proliferation and promotes apoptosis in lung squamous cell carcinoma by calcium signaling pathway.人参皂苷Rk1通过钙信号通路抑制肺鳞状细胞癌的细胞增殖并促进其凋亡。
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Mitochondrial Fission and Fusion in Tumor Progression to Metastasis.线粒体裂变与融合在肿瘤进展至转移过程中的作用
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