第二至第四指比率、成年睾酮水平和睾酮缺乏。

Second to fourth digit ratio, adult testosterone level and testosterone deficiency.

机构信息

Hospital Clínic de Barcelona - Urology Department, Spain.

出版信息

BJU Int. 2012 Jan;109(2):266-71. doi: 10.1111/j.1464-410X.2011.10249.x. Epub 2011 May 18.

DOI:10.1111/j.1464-410X.2011.10249.x

PMID:21592297

Abstract

OBJECTIVES

The ratio of the second and fourth finger lengths (2D/4D) is related to intrauterine exposure to testosterone. The relationship between 2D/4D and adult hormonal pattern is controversial. The aim of our study was to determine if there was a relationship between adult serum testosterone levels and the 2D/4D ratio.

PATIENTS AND METHODS

We prospectively recruited 204 consecutive patients referred for transrectal prostate biopsy between January 2008 and June 2009. The same physician performed clinical examinations, 2D/4D measurements and the transrectal biopsy in all cases. Cut-off points of 231 and 346 ng/dL testosterone (8 and 12 nmol/L) were used. 2D/4D determination was done with a vernier calliper on the left hand. The hormonal profile (testosterone and sexual hormone binding globulin) of the patients was determined between 7.00 am and 11.00 am. Age, weight, height, body mass index, toxic habits, digital rectal examination, prostate-specific antigen and 2D and 4D measurements were recorded prospectively.

RESULTS

The mean age was 67 ± 7 years and the mean testosterone level was 413 ± 18 ng/dL (14.33 ± 0.62 nmol/L). The percentages of patients with testosterone <231 ng/dL (8 nmol/L) and testosterone <346 ng/dL (12 nmol/L) were 6.1 and 30.6 respectively. Univariate analysis showed that low 2D/4D ratios were related to higher levels of testosterone (B=-741.98; β=-0.165, P= 0.045) and also with low prevalence of biochemical hypogonadism (testosterone <346 ng/dL). Mean 2D/4D ratio in patients with testosterone >346 ng/dL was lower than in patients with testosterone <346 ng/dL (2D/4D 0.97 ± 0.037 vs 0.99 ± 0.043 depending on their hormonal status, P= 0.05). High 2D/4D ratio was associated with low testosterone serum levels (P= 0.046).

CONCLUSIONS

The 2D/4D ratio is related to adult testosterone levels and the presence of testosterone deficiency syndrome. Patients with high 2D/4D ratios have lower testosterone levels and higher risk of testosterone deficiency syndrome.

摘要

目的

第二和第四指长度之比（2D/4D）与宫内暴露于睾丸激素有关。2D/4D 与成人激素模式之间的关系存在争议。我们的研究目的是确定成人血清睾丸激素水平与 2D/4D 比值之间是否存在关系。

患者和方法

我们前瞻性招募了 204 名连续患者，这些患者在 2008 年 1 月至 2009 年 6 月期间因直肠前列腺活检而转介。同一位医生在所有情况下进行了临床检查，2D/4D 测量和直肠活检。使用 231 和 346ng/dL 睾丸激素（8 和 12nmol/L）的截断值。使用游标卡尺在手的左侧确定 2D/4D 值。患者的激素谱（睾丸激素和性激素结合球蛋白）在上午 7.00 至 11.00 之间确定。前瞻性记录年龄，体重，身高，体重指数，毒瘾，直肠指检，前列腺特异性抗原以及 2D 和 4D 测量值。

结果

平均年龄为 67 ± 7 岁，平均睾丸激素水平为 413 ± 18ng/dL（14.33 ± 0.62nmol/L）。睾丸激素<231ng/dL（8nmol/L）和睾丸激素<346ng/dL（12nmol/L）的患者百分比分别为 6.1％和 30.6％。单因素分析表明，较低的 2D/4D 比值与较高的睾丸激素水平相关（B=-741.98；β=-0.165，P=0.045），并且与生化性腺功能减退症的低患病率也相关（睾丸激素<346ng/dL）。睾丸激素>346ng/dL 的患者的平均 2D/4D 比值低于睾丸激素<346ng/dL 的患者（2D/4D 0.97 ± 0.037 与 0.99 ± 0.043 取决于他们的激素状态，P=0.05）。高 2D/4D 比值与低血清睾丸激素水平相关（P=0.046）。