美国 20-39 岁成年男性的含糖饮料摄入与血清睾丸酮水平。
Sugar-sweetened beverage intake and serum testosterone levels in adult males 20-39 years old in the United States.
机构信息
The First Division in the Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 106th of Zhongshan Er Road, Guangzhou, 510080, China.
GuangDong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
出版信息
Reprod Biol Endocrinol. 2018 Jun 23;16(1):61. doi: 10.1186/s12958-018-0378-2.
BACKGROUND
This population-based study was designed to investigate whether consumption of sugar-sweetened beverages (SSB) is associated with lower serum total testosterone concentration in men 20-39 years old.
METHODS
All data for this study were retrieved from the National Health and Nutrition Examination Survey (NHANES) 2011-2012. The primary outcome was serum testosterone concentration, and main independent variable was SSB intake. Other variables included age, race/ethnicity, poverty/income ratio, body mass index (BMI), serum cotinine, heavy drinking, and physical activity.
RESULTS
Among all subjects (N = 545), 486 (90.4%) had normal testosterone levels (defined as ≥231 ng/dL) and 59 (9.6%) had low testosterone levels (defined as < 231 ng/dL). Multivariate logistic regression revealed the odds of low testosterone was significantly greater with increasing SSB consumption (Q4 [≥442 kcal/day] vs. Q1 [≤137 kcal/day]), adjusted odds ratio [aOR] = 2.29, p = 0.041]. After adjusting for possible confounding variables, BMI was an independent risk factor for low testosterone level; subjects with BMI ≥ 25 kg/m had a higher risk of having a low testosterone level than those with BMI < 25 kg/m (aOR = 3.68, p = 0.044).
CONCLUSION
SSB consumption is significantly associated with low serum testosterone in men 20-39 years old in the United States.
背景
本研究基于人群，旨在探究在 20-39 岁男性中，摄入含糖饮料是否与血清总睾酮浓度降低相关。
方法
本研究所有数据均来自 2011-2012 年国家健康与营养调查（NHANES）。主要结局为血清睾酮浓度，主要自变量为含糖饮料摄入。其他变量包括年龄、种族/民族、贫困/收入比、体重指数（BMI）、血清可替宁、大量饮酒和体力活动。
结果
在所有受试者（N=545）中，486 人（90.4%）睾酮水平正常（定义为≥231ng/dL），59 人（9.6%）睾酮水平较低（定义为 <231ng/dL）。多变量逻辑回归显示，随着含糖饮料摄入的增加（Q4[≥442kcal/天]比 Q1[≤137kcal/天]），低睾酮的可能性显著增加，调整后的比值比[aOR]为 2.29，p=0.041。在调整了可能的混杂变量后，BMI 是低睾酮水平的独立危险因素；BMI≥25kg/m 的受试者发生低睾酮水平的风险高于 BMI<25kg/m 的受试者（aOR=3.68，p=0.044）。
结论
在美国，20-39 岁男性中，摄入含糖饮料与血清总睾酮浓度降低显著相关。
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