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美沙酮没有年龄限制:一项回顾性队列研究。

There is no age limit for methadone: a retrospective cohort study.

机构信息

Division of Substance Use Disorders, Psychiatric Hospital of the University of Basel, Wilhelm Klein-Strasse 27, 4012 Basel, Switzerland.

出版信息

Subst Abuse Treat Prev Policy. 2011 May 18;6:9. doi: 10.1186/1747-597X-6-9.

Abstract

BACKGROUND

Data from the US indicates that methadone-maintained populations are aging, with an increase of patients aged 50 or older. Data from European methadone populations is sparse. This retrospective cohort study sought to evaluate the age trends and related developments in the methadone population of Basel-City, Switzerland.

METHODS

The study included methadone patients between April 1, 1995 and March 31, 2003. Anonymized data was taken from the methadone register of Basel-City. For analysis of age distributions, patient samples were split into four age categories from '20-29 years' to '50 years and over'. Cross-sectional comparisons were performed using patient samples of 1996 and 2003.

RESULTS

Analysis showed a significant increase in older patients between 1996 and 2003 (p < 0.001). During that period, the percentage of patients aged 50 and over rose almost tenfold, while the proportion of patients aged under 30 dropped significantly from 52.8% to 12.3%. The average methadone dose (p < 0.001) and the 1-year retention rate (p < 0.001) also increased significantly.

CONCLUSIONS

Findings point to clear trends in aging of methadone patients in Basel-City which are comparable, although less pronounced, to developments among US methadone populations. Many unanswered questions on medical, psychosocial and health economic consequences remain as the needs of older patients have not yet been evaluated extensively. However, older methadone patients, just as any other patients, should be accorded treatment appropriate to their medical condition and needs. Particular attention should be paid to adequate solutions for persons in need of care.

摘要

背景

美国的数据表明,美沙酮维持治疗人群正在老龄化,50 岁及以上患者人数增加。欧洲美沙酮人群的数据则较为匮乏。本回顾性队列研究旨在评估瑞士巴塞尔市美沙酮人群的年龄趋势和相关发展情况。

方法

该研究纳入了 1995 年 4 月 1 日至 2003 年 3 月 31 日期间的美沙酮患者。巴塞尔市美沙酮登记处提供了匿名数据。为分析年龄分布,将患者样本分为四个年龄组,从“20-29 岁”到“50 岁及以上”。使用 1996 年和 2003 年的患者样本进行了横断面比较。

结果

分析显示,老年患者在 1996 年至 2003 年间显著增加(p<0.001)。在此期间,50 岁及以上患者的比例几乎增加了十倍,而 30 岁以下患者的比例从 52.8%显著下降至 12.3%。美沙酮平均剂量(p<0.001)和 1 年保留率(p<0.001)也显著增加。

结论

研究结果表明,巴塞尔市美沙酮患者的老龄化趋势明显,与美国美沙酮人群的发展情况相似,尽管程度较轻。仍有许多关于医疗、心理社会和健康经济学后果的未解决问题,因为尚未广泛评估老年患者的需求。然而,与任何其他患者一样,老年美沙酮患者应得到与其医疗状况和需求相适应的治疗。应特别注意为有需要的人提供适当的护理解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21c1/3118116/7dc4df1f333a/1747-597X-6-9-1.jpg

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