Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Atherosclerosis. 2012 Feb;220(2):402-6. doi: 10.1016/j.atherosclerosis.2011.11.008. Epub 2011 Nov 16.
The receptor for advanced glycation end-products (RAGE) and its diverse ligands play a pivotal role in the development of cardiovascular disease. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory RAGE (esRAGE), may neutralize AGE-RAGE mediated vascular damage by acting as a decoy. (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) is a novel imaging technique for detecting vascular inflammation.
We examined vascular inflammation measured using FDG-PET in 41 type 2 diabetes patients and 41 healthy control subjects in the right carotid artery. Vascular (18)F-FDG uptake was measured as the blood-normalized standardized uptake value (SUV), known as the target-to-background ratio (TBR). In addition, their relationship with carotid intima-media thickness (CIMT), estimated GFR (eGFR), and other cardiovascular risk factors was evaluated.
Both mean and maximum TBR values were significantly higher in patients with type 2 diabetes compared to healthy subjects. After adjusting for age and gender, sRAGE levels were significantly correlated with both mean and maximum TBR values, but not with CIMT values. Multiple linear regression analysis showed that maximum TBR values were independently associated with sRAGE levels in addition to HbA1c and eGFR.
Circulating sRAGE showed significant association with TBR values measured using FDG-PET, which reflect vascular inflammation.
晚期糖基化终产物受体（RAGE）及其多种配体在心血管疾病的发展中起着关键作用。RAGE 的可溶性形式（sRAGE），包括剪接变异体内源性分泌型 RAGE（esRAGE），可以通过充当诱饵来中和 AGE-RAGE 介导的血管损伤。（18）F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）是一种检测血管炎症的新型成像技术。
我们在 41 名 2 型糖尿病患者和 41 名健康对照者的右侧颈动脉中检查了使用 FDG-PET 测量的血管炎症。血管（18）F-FDG 摄取量作为血液标准化摄取值（SUV）进行测量，称为靶背比（TBR）。此外，还评估了它们与颈动脉内膜中层厚度（CIMT）、估算肾小球滤过率（eGFR）和其他心血管危险因素的关系。
与健康受试者相比，2 型糖尿病患者的平均和最大 TBR 值均显著升高。在校正年龄和性别后，sRAGE 水平与平均和最大 TBR 值均呈显著相关，但与 CIMT 值无关。多元线性回归分析显示，除了 HbA1c 和 eGFR 外，最大 TBR 值还与 sRAGE 水平独立相关。
循环 sRAGE 与 FDG-PET 测量的 TBR 值显著相关，反映了血管炎症。
