Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
J Pediatr. 2011 Oct;159(4):597-601.e1. doi: 10.1016/j.jpeds.2011.03.049. Epub 2011 May 17.
To evaluate the prevalence of postprandial hypoglycemia (PPH) after fundoplasty after the initiation of a universal postoperative glucose surveillance plan in the neonatal intensive care unit (NICU).
This was a retrospective chart review of children (newborn to 18 years) who underwent fundoplasty at The Children's Hospital of Philadelphia during the 2-year-period after the launch of a surveillance protocol in the NICU and other units. The rate of screening, frequency of PPH (postprandial blood glucose <60 mg/dL [3.3 mmol/L] on 2 occasions), frequency of postprandial hyperglycemia preceding PPH, timing of PPH presentation, and related symptoms were evaluated.
A total of 285 children were included (n = 64 in the NICU; n = 221 in other units). Of the children screened in all units, 24.0% showed evidence of PPH, compared with 1.3% of unscreened children. Hyperglycemia preceded PPH in 67.7% (21/31) of all screened children. Within the NICU, most children had PPH within 1 week, but only 53.3% exhibited symptoms of dumping syndrome.
This study supports the use of universal postoperative blood glucose surveillance in identifying PPH in children after fundoplasty. Earlier identification of PPH would lead to earlier treatment and minimize the effects of unidentified hypoglycemic events.
评估新生儿重症监护病房(NICU)启动普遍术后血糖监测计划后,肠旋转不良术后发生餐后低血糖(PPH)的患病率。
这是一项回顾性图表研究,研究对象为在 NICU 及其他科室启动监测方案后 2 年内接受肠旋转不良手术的费城儿童医院(The Children's Hospital of Philadelphia)患儿(新生儿至 18 岁)。评估了筛查率、PPH 发生率(2 次餐后血糖<60mg/dL[3.3mmol/L])、PPH 前餐后高血糖的发生率、PPH 出现时间以及相关症状。
共纳入 285 例患儿(NICU 64 例,其他科室 221 例)。所有科室筛查患儿中,24.0%存在 PPH 证据,而未筛查患儿中仅 1.3%存在 PPH。所有筛查患儿中,67.7%(21/31)的患儿出现 PPH 前存在高血糖。在 NICU 中,大多数患儿在术后 1 周内出现 PPH,但仅有 53.3%出现倾倒综合征症状。
本研究支持对肠旋转不良术后患儿采用普遍术后血糖监测来识别 PPH。更早地识别 PPH 将导致更早地治疗,并最大程度减少未识别的低血糖事件的影响。