Sloan-Kettering Institute, 1275 York Ave, Box 252, New York, NY 10065, USA.
Curr Opin Genet Dev. 2011 Aug;21(4):504-10. doi: 10.1016/j.gde.2011.04.010. Epub 2011 May 16.
A limited set of cell-cell signaling pathways presides over the vast majority of animal developmental events. The typical raison d'etre for signal transduction is to control the transcription of protein-coding genes. However, with the recent appreciation of microRNAs, growing attention has been paid towards understanding how signaling pathways intertwine with microRNA-mediated regulation. This review highlights recent studies that uncover unexpected modes of microRNA regulation by cell signaling pathways. Not only can miRNA transcription be positively or negatively regulated by cell signaling, the TGF-β/BMP pathways and Ras/MAPK pathways have now been shown to directly influence microRNA biogenesis to mediate substantial cellular phenotypes.
有限的细胞间信号通路支配着绝大多数动物发育事件。信号转导的典型存在理由是控制蛋白编码基因的转录。然而，随着对 microRNAs 的最新认识，人们越来越关注理解信号通路如何与 microRNA 介导的调控交织在一起。这篇综述强调了最近的研究，这些研究揭示了细胞信号通路对 microRNA 调节的意外模式。不仅 miRNA 的转录可以被细胞信号正向或负向调节，TGF-β/BMP 通路和 Ras/MAPK 通路现在已经被证明可以直接影响 microRNA 的生物发生，从而介导实质性的细胞表型。
