King's College London, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom.
Neurobiol Aging. 2010 May;31(5):886-7. doi: 10.1016/j.neurobiolaging.2008.06.006. Epub 2008 Jul 21.
Modification of the effect of life events on risk of depression by a polymorphism in the serotonin transporter gene promoter (5-HTTLPR) has been reported in child, adolescent, adult and elderly populations. Replication attempted on data collected from 1421 individuals aged 65 and over from a French community study provided no evidence of a similar modifying effect. In the only analysis known to the authors to be carried out in an exclusively elderly, European population, this null finding remained consistent after restriction of analysis to prevalent or incident cases.
生活事件对抑郁症风险的影响可被 5-羟色胺转运体基因启动子（5-HTTLPR）多态性修饰，这在儿童、青少年、成年和老年人群中均有报道。对来自法国社区研究的 1421 名 65 岁及以上个体的数据集进行的重复分析并未提供类似修饰作用的证据。在作者所知的唯一一项专门在老年欧洲人群中进行的分析中，在将分析仅限于现患或新发病例后，这一无效发现仍然一致。
