Research School of Biology, Australian National University, Canberra, Australia.
J Alzheimers Dis. 2011;26(2):201-5. doi: 10.3233/JAD-2011-110266.
Both tumor necrosis factor (TNF) and leptin are, independently, under investigation as the central mechanism for Alzheimer's disease. The wider literature provides every indication that both mediators are part of the same pathways thought to cause functional loss in this condition. This association, which has not been specifically addressed in the Alzheimer's disease literature, may be a useful link to expedite future study into the pathogenesis of this condition.
肿瘤坏死因子（TNF）和瘦素都被独立地作为阿尔茨海默病的中心机制进行研究。更广泛的文献表明，这两种介质都属于同一途径的一部分，而该途径被认为会导致这种疾病的功能丧失。这种关联在阿尔茨海默病文献中尚未具体涉及，可能是一个有用的联系，有助于加速对这种疾病发病机制的未来研究。
