Ülker Mustafa, Kenangil Gülay
Erenköy Mental and Neurological Diseases Hospital, Neurology Clinic, İstanbul, Turkey.
Noro Psikiyatr Ars. 2018 Jun 5;55(3):211-214. doi: 10.5152/npa.2017.16978. eCollection 2018 Sep.
To investigate the relation of circulating levels of leptin with cognition in Alzheimer's disease (AD) patients.
Thirty patients meeting the clinical diagnostic criteria for AD, and twenty-five healthy controls were enrolled into the study. At baseline, all patients underwent standing height, weight measurements, and waist circumference (in centimeters) using a standard scale. Body mass index (BMI) was then calculated as weight (in kilograms). A single 5-ml fasting blood sample was obtained from each patient. All subjects were evaluated by Turkish version of Mini Mental State Examination (MMSE), Clinical Dementia Rating (CDR) and Global Deterioration Scale (GDS).
The mean age of patients and controls were 72.33±10.11 and 67.20±8.95, respectively. There was not any significant difference between age of the patients and the controls (p=0.054). Both patient and control groups consisted of mostly women (60% and 56% respectively). The mean waist circumferences (WC) of patients and controls were 95.46±10.87 and 97.76±10.07, respectively and was not statistically different (p=0.424). The mean serum leptin levels in patients and controls were 5.49±4.06 ng/dL 5.71±4.45 ng/dL, respectively. Leptin levels were not statistically different between patients and controls (p=0.84). The mean MMSE scores of AD patients and controls were 17±6.54 and 27.32±2.15 respectively, and AD patients had significantly lower MMSE scores than the controls (p=0.000). The mean BMI of patients and controls were 25.72±3.98 and 27.92±3.08 respectively. The BMI of controls were higher than patients and there was statistically significant difference between two groups (p=0.029). In the patient group, there were no correlations between leptin levels and age (p=0.067), BMI (p=0.098), WC (p=0.113), MMSE (p=0.203), CDR (p=0.519) and GDS (p=0.587). Similarly in control group leptin levels were not correlated with BMI (p=0.718), WC (p=0.755) and MMSE (p=0.859).
In the present study, we could not find any relation between blood leptin levels and cognition in AD patients.
研究阿尔茨海默病（AD）患者循环瘦素水平与认知功能的关系。
30例符合AD临床诊断标准的患者和25例健康对照者纳入本研究。基线时，所有患者使用标准秤测量身高、体重和腰围（厘米）。然后计算体重指数（BMI），单位为千克。从每位患者采集一份5毫升空腹血样。所有受试者均接受土耳其语版简易精神状态检查表（MMSE）、临床痴呆评定量表（CDR）和总体衰退量表（GDS）评估。
患者和对照组的平均年龄分别为72.33±10.11岁和67.20±8.95岁。患者与对照组年龄无显著差异（p = 0.054）。患者组和对照组女性居多（分别为60%和56%）。患者和对照组的平均腰围（WC）分别为95.46±10.87厘米和97.76±10.07厘米，无统计学差异（p = 0.424）。患者和对照组的平均血清瘦素水平分别为5.49±4.06 ng/dL和5.71±4.45 ng/dL。患者与对照组的瘦素水平无统计学差异（p = 0.84）。AD患者和对照组的平均MMSE评分分别为17±6.54分和27.32±2.15分，AD患者的MMSE评分显著低于对照组（p = 0.000）。患者和对照组的平均BMI分别为25.72±3.98和27.92±3.08。对照组的BMI高于患者，两组间有统计学显著差异（p = 0.029）。在患者组中，瘦素水平与年龄（p = 0.067）、BMI（p = 0.098）、WC（p = 0.113）、MMSE（p = 0.203）、CDR（p = 0.519）和GDS（p = 0.587）均无相关性。同样，在对照组中，瘦素水平与BMI（p = 0.718）、WC（p = 0.755）和MMSE（p = 0.859）也无相关性。
在本研究中，我们未发现AD患者血瘦素水平与认知功能之间存在任何关联。
