University of Turin, Italy.
Organogenesis. 2011 Apr-Jun;7(2):116-22. doi: 10.4161/org.7.2.16284. Epub 2011 Apr 1.
Impressive progress has been made since the turn of the century in the field of stem cells. Different types of stem cells have now been isolated from different types of tissues. Pluripotent stem cells are the most promising cell source for organ regeneration. One such cell type is the germline cell-derived pluripotent cell, which is derived from adult spermatogonial stem cells. The germline cell-derived pluripotent stem cells have been obtained from both human and mouse and, importantly, are adult stem cells with embryonic stem cell-like properties that do not require specific manipulations for pluripotency acquisition, hence bypassing problems related to induced pluripotent stem cells and embryonic stem cells. The germline cell-derived pluripotent stem cells have been induced to differentiate into cells deriving from the three germ layers and shown to be functional in vitro. This review will discuss the plasticity of the germline cell-derived pluripotent stem cells and their potential applications in human organ regeneration, with special emphasis on liver regeneration. Potential problems related to their use are also highlighted.
自本世纪初以来，干细胞领域取得了令人瞩目的进展。现在已经从不同类型的组织中分离出不同类型的干细胞。多能干细胞是器官再生最有前途的细胞来源。此类细胞之一是生殖细胞衍生的多能细胞，它来源于成年精原干细胞。已经从人和小鼠中获得了生殖细胞衍生的多能干细胞，重要的是，它们是具有胚胎干细胞样特性的成体干细胞，不需要特定的操作来获得多能性，因此避免了与诱导多能干细胞和胚胎干细胞相关的问题。已经诱导生殖细胞衍生的多能干细胞分化为来自三个胚层的细胞，并在体外显示出功能。这篇综述将讨论生殖细胞衍生的多能干细胞的可塑性及其在人类器官再生中的潜在应用，特别强调肝脏再生。还强调了与它们的使用相关的潜在问题。
