Abrahámová J, Májský A, Fucíková T, Koutecký J
Onkologie. 1978 Oct;1(5):177-9. doi: 10.1159/000213946.
In 45 patients with Wilms' tumor of the kidney the IgG, IgA, and IgM serum immunoglobulin levels were quantitated and 23 antigens of HLA-A and HLA-B locues were typed on the same patients' lymphocytes. In 22 individuals with increased IgA immunoglobulin level a more frequent incidence of HLA-A 1 antigen was found. This antigen was established in 62.5% of patients with IgA levels higher than 200 IU/ml. Considering the fact that 86.35% of the patients survive two years, and 16 of 22 patients (= 72.72%) are practically cured, it is suggested that the simultaneous occurrence of increased levels of IgA immunoglobulin and of HLA antigen A 1, is a favourable prognostic sign.
对45例肾母细胞瘤患者的血清免疫球蛋白IgG、IgA和IgM水平进行了定量分析，并对同一患者的淋巴细胞进行了HLA - A和HLA - B位点的23种抗原分型。在22例IgA免疫球蛋白水平升高的个体中，发现HLA - A1抗原的发生率更高。在IgA水平高于200 IU/ml的患者中，该抗原的检出率为62.5%。鉴于86.35%的患者存活两年，22例患者中有16例（= 72.72%）基本治愈，提示IgA免疫球蛋白水平升高与HLA抗原A1同时出现是一个良好的预后指标。
