癫痫的IgA缺乏患者的免疫异常和HLA抗原频率
Immunological abnormalities and HLA antigen frequencies in IgA deficient patients with epilepsy.
作者信息
Fontana A, Joller H, Skvaril F, Grob P
出版信息
J Neurol Neurosurg Psychiatry. 1978 Jul;41(7):593-7. doi: 10.1136/jnnp.41.7.593.
Abstract
Twenty-three epileptics with constitutional factors for seizures and low IgA serum concentrations were studied. Imbalance of the IgG subclasses was often observed, the IgG4 being undetectable in 13 (65%) patients. The percentage of circulating lymphocytes positive for surface immunoglobulins was normal except for slightly increased values for IgA in six (28.5%) patients. Of the epileptics, 48% showed subnormal proportions of lymphocytes forming spontaneous rosettes. There was a distinct trend for HLA-A2 antigen in the patients tested.
摘要
对23名具有癫痫发作体质因素且血清IgA浓度较低的癫痫患者进行了研究。经常观察到IgG亚类失衡，13名（65%）患者检测不到IgG4。除6名（28.5%）患者的IgA值略有升高外，表面免疫球蛋白阳性的循环淋巴细胞百分比正常。在癫痫患者中，48%的患者形成自发玫瑰花结的淋巴细胞比例低于正常水平。在接受检测的患者中，HLA - A2抗原存在明显的趋势。
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