Department of Biomedical Engineering and Physics, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
J Biophotonics. 2011 Oct;4(10):759-67. doi: 10.1002/jbio.201100021. Epub 2011 May 19.
Bruises become spatially inhomogeneous during the healing process; a smaller red-blue core area, caused by hemoglobin, is surrounded by a larger yellow area, caused by bilirubin, which is enzymatically formed from hemoglobin. These two areas develop at different rates and hence carry information about the age of the bruise. We present a proof of principle demonstration that the age of bruises can be determined via an inverse procedure using a mathematical model and daily measurements of these two areas using a hyperspectral imaging system. The inaccuracy found is 2.3% for fresh bruises and 3 to 24% for bruises up to 3 days old. In conclusion, color inhomogeneity of bruises can be used to determine their age. We expect that future age determination of bruises by the inverse procedure described here, possibly also including the distribution of concentrations in the areas will open up a new phase in clinical bruise classification.
在愈合过程中，淤青会呈现出空间上的不均匀性；一个较小的红蓝色核心区域是由血红蛋白引起的，周围是一个较大的黄色区域，是由胆红素引起的，胆红素是由血红蛋白酶促形成的。这两个区域以不同的速度发展，因此携带了关于淤青年龄的信息。我们提出了一个原理验证，即可以通过使用数学模型和使用高光谱成像系统对这两个区域进行日常测量的逆过程来确定淤青的年龄。对于新鲜的淤青，发现的不准确性为 2.3%，对于 3 天内的淤青为 3 到 24%。总之，淤青的颜色不均匀性可用于确定其年龄。我们预计，这里描述的逆过程对淤青年龄的未来确定，可能还包括区域内浓度的分布，将为临床淤青分类开辟一个新的阶段。
