Shibasaki Tadao, Seino Susumu
Division of Cellular and Molecular Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine.
Nihon Rinsho. 2011 May;69(5):803-7.
Incretin hormones GIP(glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) improve glycemic control by potentiating glucose-induced insulin secretion in pancreatic beta-cells and also have beneficial effects on appetite control and body weight. In response to food ingestion, GIP and GLP-1 are secreted from enteroendocrine K- and L-cells, respectively. In these cells, it is shown that a variety of molecular sensors are involved in the detection of carbohydrates, lipids, and proteins. In view of development of new incretin-related drugs, these sensors are attractive targets to enhance the endogenous pools of incretins.
肠促胰岛素激素GIP（葡萄糖依赖性促胰岛素多肽）和GLP-1（胰高血糖素样肽-1）通过增强胰腺β细胞中葡萄糖诱导的胰岛素分泌来改善血糖控制，并且对食欲控制和体重也有有益作用。响应食物摄入，GIP和GLP-1分别从肠内分泌K细胞和L细胞分泌。在这些细胞中，已表明多种分子传感器参与碳水化合物、脂质和蛋白质的检测。鉴于新型肠促胰岛素相关药物的开发，这些传感器是增加内源性肠促胰岛素储备的有吸引力的靶点。
