Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.
Ocul Immunol Inflamm. 2011 Jun;19(3):167-70. doi: 10.3109/09273948.2011.560411.
To report a case of a patient with optic nerve involvement in neuro-Sweet syndrome and review the literature on this systemic disease.
Interventional case report and review of the literature.
A 49-year-old man developed an acute exacerbation of bilateral panuveitis and optic disc edema together with symptoms of a papular rash on his forearms, fevers, malaise, and arthalgias. Laboratory findings revealed an aseptic meningitis and neutrophilic leukocytosis. Biopsy of the skin rash demonstrated an intense neutrophilic infiltrate in the dermis consistent with the diagnosis of neuro-Sweet syndrome. The patient continued to require corticosteroids for inflammation control in spite of immunomodulatory therapies, including tumor necrosis factor-alpha inhibitor infliximab.
Sweet syndrome can present with optic nerve involvement. Screening for underlying etiologies, including autoimmune disease, malignancy, and offending drugs, is important for targeted therapy.
报告一例伴有视神经受累的神经型Sweet 综合征病例，并复习该全身性疾病的文献。
介入性病例报告和文献复习。
一名 49 岁男性出现双侧全葡萄膜炎和视盘水肿急性加重，同时在前臂出现斑丘疹、发热、不适和关节痛等症状。实验室检查发现无菌性脑膜炎和中性粒细胞增多。皮疹活检显示真皮内有强烈的中性粒细胞浸润，符合神经型 Sweet 综合征的诊断。尽管采用了免疫调节疗法，包括肿瘤坏死因子-α抑制剂英夫利昔单抗，该患者仍需继续使用皮质类固醇控制炎症。
Sweet 综合征可伴有视神经受累。筛查潜在病因，包括自身免疫性疾病、恶性肿瘤和致病药物，对靶向治疗很重要。
