Department of Internal Medicine, Section Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Clin Endocrinol (Oxf). 2011 Nov;75(5):608-13. doi: 10.1111/j.1365-2265.2011.04110.x.
Recent evidence indicates that a lower plasma level of 25-hydroxyvitamin D (25 OHD) is associated with a higher risk of the metabolic syndrome. It has not been studied in older people with a high prevalence of vitamin D insufficiency.
This study investigates the association between vitamin D status and the metabolic syndrome in community-dwelling older persons in the Netherlands.
The study is part of the Longitudinal Aging Study Amsterdam, an ongoing cohort study in a representative sample of Dutch older persons. A total of 1286 subjects (629 men and 657 women) between the ages of 65 and 88 years participated in the study.
Metabolic syndrome (U.S. National Cholesterol Education Program definition) and its individual components were assessed as well as serum 25 OHD levels.
Among the participants, the prevalence of the metabolic syndrome was 37·0%. The mean 25 OHD level was 53·3 nM; 47·8% had 25 OHD levels below 50 nM. There was a significantly increased risk of the metabolic syndrome in the subjects with serum 25 OHD levels below 50 nM, compared with that of subjects with levels over 50 nM [odds ratio (OR) = 1·54; 95% confidence interval (CI) 1·23-1·94]. After adjustment for confounders, age, sex, season, years of education, alcohol use, total activity, smoking and PTH, the OR was 1·29 (95% CI 1·00-1·68). The association between vitamin D deficiency and the metabolic syndrome was mainly determined by the components low HDL and (high) waist circumference.
Vitamin D deficiency is common in the older population in the Netherlands, and subjects with serum 25 OHD below 50 nM have a higher risk of the metabolic syndrome.
最近的证据表明，血浆中 25-羟维生素 D（25OHD）水平较低与代谢综合征的风险增加有关。但在维生素 D 不足的老年人中，这一现象尚未得到研究。
本研究旨在调查荷兰社区居住的老年人中维生素 D 状况与代谢综合征之间的关系。
本研究是阿姆斯特丹纵向老龄化研究的一部分，该研究是一项针对荷兰老年人代表性样本的正在进行的队列研究。共有 1286 名年龄在 65 至 88 岁之间的受试者（629 名男性和 657 名女性）参与了该研究。
评估了代谢综合征（美国国家胆固醇教育计划定义）及其各个组成部分以及血清 25OHD 水平。
在参与者中，代谢综合征的患病率为 37.0%。平均 25OHD 水平为 53.3 nM；47.8%的人 25OHD 水平低于 50 nM。与 25OHD 水平高于 50 nM 的受试者相比，血清 25OHD 水平低于 50 nM 的受试者患代谢综合征的风险显著增加[比值比（OR）=1.54；95%置信区间（CI）1.23-1.94]。在调整混杂因素后，年龄、性别、季节、受教育年限、饮酒、总活动量、吸烟和甲状旁腺激素后，OR 为 1.29（95%CI 1.00-1.68）。维生素 D 缺乏与代谢综合征之间的关联主要由低 HDL 和（高）腰围组成部分决定。
荷兰老年人群中维生素 D 缺乏很常见，血清 25OHD 低于 50 nM 的受试者患代谢综合征的风险更高。
