Tanaka Motoko, Tokunaga Koki, Maruyama Toru, Otagiri Masaki, Tominaga Yoshihiro, Itoh Kazuko, Matsushita Kazutaka, Komaba Hirotaka, Fukagawa Masafumi
Department of Nephrology, Akebono Clinic, Kumamoto, Japan.
Ther Apher Dial. 2011 Jun;15 Suppl 1:38-41. doi: 10.1111/j.1744-9987.2011.00925.x.
Parathyroidectomy for hyperparathyroidism has been associated with a survival benefit, but the mechanisms remain unclear. We are reporting on an 88-year-old female patient who had high serum calcium and intact parathyroid hormone levels associated with an enlarged parathyroid gland. A parathyroidectomy was performed due to a diagnosis of primary hyperparathyroidism. After the surgery, there was a marked decrease in the oxidative stress markers, such as the ratios of oxidized to unoxidized albumin and advanced oxidation protein products. These results suggest that parathyroidectomy reduces oxidative stress in patients with primary hyperparathyroidism, which may in part explain the reduced risk for cardiovascular and all-cause mortality after parathyroidectomy.
甲状旁腺切除术治疗甲状旁腺功能亢进症与生存获益相关，但其机制尚不清楚。我们报告了一名88岁女性患者，其血清钙和完整甲状旁腺激素水平升高，伴有甲状旁腺肿大。因诊断为原发性甲状旁腺功能亢进症而进行了甲状旁腺切除术。手术后，氧化应激标志物显著下降，如氧化型与未氧化型白蛋白的比率以及晚期氧化蛋白产物。这些结果表明，甲状旁腺切除术可降低原发性甲状旁腺功能亢进症患者的氧化应激，这可能部分解释了甲状旁腺切除术后心血管疾病及全因死亡率降低的原因。
