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本文引用的文献

1
Oxidative stress and angiogenesis in primary hyperparathyroidism.原发性甲状旁腺功能亢进症中的氧化应激与血管生成
Eur Surg. 2017;49(3):118-126. doi: 10.1007/s10353-016-0457-6. Epub 2016 Dec 14.
2
Primary hyperparathyroidism: review and recommendations on evaluation, diagnosis, and management. A Canadian and international consensus.原发性甲状旁腺功能亢进症：关于评估、诊断和管理的综述与建议。加拿大及国际共识。
Osteoporos Int. 2017 Jan;28(1):1-19. doi: 10.1007/s00198-016-3716-2. Epub 2016 Sep 9.
3
Primary hyperparathyroidism.原发性甲状旁腺功能亢进症
Ulus Cerrahi Derg. 2016 Mar 1;32(1):58-66. doi: 10.5152/UCD.2015.3032. eCollection 2016.
4
Thiobarbituric acid reactive substances (TBARS) is a state biomarker of oxidative stress in bipolar patients in a manic phase.硫代巴比妥酸反应物质（TBARS）是躁狂期双相情感障碍患者氧化应激的状态生物标志物。
J Affect Disord. 2015 Mar 1;173:22-6. doi: 10.1016/j.jad.2014.10.045. Epub 2014 Nov 4.
5
Surgery for primary hyperparathyroidism.原发性甲状旁腺功能亢进的手术治疗。
Cancer. 2014 Dec 1;120(23):3602-16. doi: 10.1002/cncr.28891. Epub 2014 Jul 9.
6
Parathyroidectomy markedly reduces oxidative stress in a patient with primary hyperparathyroidism.甲状旁腺切除术可显著降低原发性甲状旁腺功能亢进患者的氧化应激水平。
Ther Apher Dial. 2011 Jun;15 Suppl 1:38-41. doi: 10.1111/j.1744-9987.2011.00925.x.
7
Oxidative stress caused by mitochondrial calcium overload.线粒体钙超载引起的氧化应激。
Ann N Y Acad Sci. 2010 Jul;1201:183-8. doi: 10.1111/j.1749-6632.2010.05634.x.
8
8-Hydroxydeoxyguanosine: a new potential independent prognostic factor in breast cancer.8-羟基脱氧鸟苷：乳腺癌新的潜在独立预后因素。
Br J Cancer. 2010 Mar 16;102(6):1018-23. doi: 10.1038/sj.bjc.6605565. Epub 2010 Feb 23.
9
2009 EANM parathyroid guidelines.2009年欧洲核医学协会甲状旁腺指南。
Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1201-16. doi: 10.1007/s00259-009-1131-z.
10
The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years.原发性甲状旁腺功能亢进症在接受或未接受甲状旁腺手术后15年的自然病史。
J Clin Endocrinol Metab. 2008 Sep;93(9):3462-70. doi: 10.1210/jc.2007-1215. Epub 2008 Jun 10.

甲状旁腺切除术对原发性甲状旁腺功能亢进症患者氧化应激的影响

EFFECT OF PARATHYROIDECTOMY ON OXIDATIVE STRESS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM.

作者信息

Abdulrahman S M F, Kilboz B B, Teksöz D, Soylu S, Bolayirli M, Teksöz S

机构信息

Department of General Surgery, Istanbul University-Cerrahpaşa, Medical Faculty, Istanbul, Turkey.

Bakirkoy Sadi Konuk Teaching and Research Hospital, Department of Clinical Biochemistry, Istanbul, Turkey.

出版信息

Acta Endocrinol (Buchar). 2022 Jan-Mar;18(1):20-23. doi: 10.4183/aeb.2022.20.

DOI:10.4183/aeb.2022.20
PMID:35975258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9365408/
Abstract

INTRODUCTION

Primary hyperparathyroidism is diagnosed earlier and more frequently with the introduction of routine serum calcium measurements. In literature, it is shown that mortality and morbidity decrease after parathyroidectomy. In our study, we aimed to determine the effect of parathyroidectomy on oxidative stress.

MATERIALS AND METHODS

The results of 41 patients who underwent parathyroidectomy for primary hyperparathyroidism between March 2018 and end of December 2018 were evaluated prospectively. Total antioxidant capacity (TAC), superoxide dismutase (SOD), thiobarbituric acid reactive substances (TBARS), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), parathyroid hormone, calcium and albumin were measured before and after parathyroidectomy.

RESULTS

The mean age of the patients in the study was 45 ± 13.1 years (age range: 18-76 years). The female/male ratio was 32/9. Postoperative values of 8OHdG, MDA and SOD 1 were significantly lower than preoperative values (p <0.05). There was no significant difference between preoperative and postoperative TAC and TBARS values.

CONCLUSION

Oxidative stress decreased in patients with primary hyperparathyroidism after parathyroidectomy. Randomized prospective studies are needed to show the relationship between biochemical and clinical parameters in order to see the clinical reflection of the study.

摘要

引言

随着常规血清钙检测的引入，原发性甲状旁腺功能亢进症的诊断更早且更频繁。文献表明，甲状旁腺切除术后死亡率和发病率会降低。在我们的研究中，我们旨在确定甲状旁腺切除术对氧化应激的影响。

材料与方法

对2018年3月至2018年12月底因原发性甲状旁腺功能亢进症接受甲状旁腺切除术的41例患者的结果进行前瞻性评估。在甲状旁腺切除术前和术后测量总抗氧化能力（TAC）、超氧化物歧化酶（SOD）、硫代巴比妥酸反应性物质（TBARS）、8-羟基-2'-脱氧鸟苷（8-OHdG）、丙二醛（MDA）、甲状旁腺激素、钙和白蛋白。

结果

研究中患者的平均年龄为45±13.1岁（年龄范围：18 - 76岁）。女性/男性比例为32/9。8-OHdG、MDA和SOD 1的术后值显著低于术前值（p<0.05）。术前和术后TAC和TBARS值之间无显著差异。

结论

原发性甲状旁腺功能亢进症患者在甲状旁腺切除术后氧化应激降低。需要进行随机前瞻性研究以显示生化和临床参数之间的关系，以便观察该研究的临床反映。